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Modified hGRF(1-44) analog
Tesamorelin is a synthetic analog of the 44-residue growth-hormone-releasing factor sequence, hGRF(1-44), supplied as a lyophilized reference material in a single 10mg vial with a published certificate of analysis.
Tesamorelin is a synthetic analog of the 44-residue growth-hormone-releasing factor sequence, written hGRF(1-44) and equivalently GHRH(1-44). Growth-hormone-releasing factor and growth-hormone-releasing hormone are two naming conventions for the same endogenous peptide, and catalog listings use GRF and GHRH interchangeably, so the two designations are not evidence of two different materials. The class designation records that the parent sequence is modified; the nature of that modification is not described here, because it is not stated in the documentation this page is built from. The molecular formula is C221H366N72O67S at approximately 5136 g/mol, under PubChem CID 16137828, with InChIKey QBEPNUQJQWDYKU-BMGKTWPMSA-N. The stated formula and the stated mass reconcile, and the check can be run without leaving this page: 221 carbon atoms at 12.011 contribute 2654.43, 366 hydrogen at 1.008 contribute 368.93, 72 nitrogen at 14.007 contribute 1008.50, 67 oxygen at 15.999 contribute 1071.93, and one sulfur contributes 32.06, summing to 5135.86 g/mol, which is the 5136 figure carried here. That single unsubscripted S is worth reading on a chain this long: across 44 residues the formula accounts for exactly one sulfur atom. Investigated in laboratory research into growth-hormone-releasing hormone signaling pathways. Supplied as a lyophilized reference material in a single 10mg size; identity and purity characterized by ultra-high-performance liquid chromatography with mass spectrometry, against a specification of 98 percent minimum. The appearance recorded on the certificate is white lyophilized powder. It is not supplied as a solution, a suspension, or any other prepared formulation. Stored desiccated at 68°F (20°C), away from light and moisture.
>99% UPLC purity; identity confirmed by mass spectrometry. A Certificate of Analysis is published for each size, reporting that lot's identity and purity result. See our quality & COA page.
Supplied as a lyophilized reference material. Lyophilized reference materials are stored desiccated at 68°F (20°C), away from light and moisture. We do not provide reconstitution, preparation, or usage instructions of any kind.
Tesamorelin is a synthetic peptide built on the 44-residue growth-hormone-releasing factor sequence, hGRF(1-44). Two naming conventions describe the same parent molecule: growth-hormone-releasing factor, abbreviated GRF, and growth-hormone-releasing hormone, abbreviated GHRH. A listing that reads GRF(1-44) and one that reads GHRH(1-44) are pointing at the same 44-residue chain, so the two designations are not evidence of two different materials. The 44 in that designation is also what separates this compound from the analogs built on the shortened 29-residue fragment, which are listed elsewhere in this catalog under their own names. Identity on this page rests on three keys: the molecular formula C221H366N72O67S, a molecular weight of approximately 5136 g/mol, and PubChem CID 16137828.
The molecular formula is C221H366N72O67S and the molecular weight is approximately 5136 g/mol, both referencing PubChem CID 16137828. Those two figures are internally consistent, and the check runs on the page: 221 carbon at 12.011 contributes 2654.43, 366 hydrogen at 1.008 contributes 368.93, 72 nitrogen at 14.007 contributes 1008.50, 67 oxygen at 15.999 contributes 1071.93, and the single sulfur contributes 32.06. The sum is 5135.86 g/mol, which rounds to the figure printed here. The InChIKey is QBEPNUQJQWDYKU-BMGKTWPMSA-N. On a molecule of this size a mass is easy to transcribe with a digit out of place, so a third-party listing is best checked against the formula and the InChIKey rather than against the mass alone.
A certificate is published for this listing at /coa/tesamorelin-10mg.pdf and carries the date its analysis was conducted. The method printed on the document is qualitative and quantitative chemical analysis by ultra-high-performance liquid chromatography with mass spectrometry, against a purity specification of 98 percent minimum. The two headline entries answer different questions. Mass spectrometry establishes identity, matching an observed molecular ion against the expected mass of the named species. The chromatographic purity figure is area-percent, the integrated area of the main peak divided by the total integrated peak area, which is a relative measure of chromatographically resolved organic impurities rather than an assay of absolute content. It does not account for water, residual solvent, counter-ion mass, or any species that neither retains on the column nor absorbs at the detection wavelength. The certificate also does not report water or moisture content, residual solvent, net peptide content by nitrogen determination, endotoxin, or bioburden. Anything absent from the certificate is not certified by it, and the document itself, not this page, is the record of what was measured on the material shipped.
Tesamorelin ships as a dry lyophilized reference material in a sealed vial, in a single 10mg size. Lyophilization is freeze-drying: water is removed by sublimation from the frozen state under reduced pressure, which leaves a porous cake or powder rather than a compacted solid. The certificate for this listing records the appearance as white lyophilized powder, which is what a vial of this material should look like on arrival. It is not supplied as a solution, a suspension, or any other prepared formulation, and no preparation guidance accompanies it. Storage is desiccated at 68°F (20°C), away from light and moisture. That figure is the house storage condition stated across this catalog and is not a typographical error for a freezer temperature.
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